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•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•Why Your Lungs May Hold the Secret to Your Stress Levels•Walking in Fear: Why Nepal’s Streets Aren't Safe and the Race to Stop a "Hidden Killer"•Why Poor Living and Working Conditions are Shattering the Mental Health of Nepali Workers•Silent Suffering: Why Nepal’s Doctors and Nurses Are Not Reporting Child Abuse•New Study Highlights Metabolism Risks in Combination Antidepressant Therapy in Nepal•New Study Reveals Hidden Environmental Drivers Behind Nepal’s Ongoing Cholera Battle•The Silent Pandemic: Kathmandu’s Poultry Industry Is Breeding Untreatable Superbugs•The Silent Emergency: Domestic Violence and the Mental Health Crisis Among Nepalese Women•Nepal’s Drug-Resistant TB Rates Hold Steady, but New Antibiotic Resistance Sparks Concern•How Missing Checklists and Protocols are Costing Lives in Nepal’s ERs•Why Your Lungs May Hold the Secret to Your Stress Levels•Walking in Fear: Why Nepal’s Streets Aren't Safe and the Race to Stop a "Hidden Killer"•Why Poor Living and Working Conditions are Shattering the Mental Health of Nepali Workers•Silent Suffering: Why Nepal’s Doctors and Nurses Are Not Reporting Child Abuse•New Study Highlights Metabolism Risks in Combination Antidepressant Therapy in Nepal•New Study Reveals Hidden Environmental Drivers Behind Nepal’s Ongoing Cholera Battle•The Silent Pandemic: Kathmandu’s Poultry Industry Is Breeding Untreatable Superbugs•The Silent Emergency: Domestic Violence and the Mental Health Crisis Among Nepalese Women•Nepal’s Drug-Resistant TB Rates Hold Steady, but New Antibiotic Resistance Sparks Concern

clinical trials

Live updates directly from PubMed Research

Adaptive trial design and interim decision-making using incomplete longitudinal measurements: Methods and application to myasthenia gravis

Sample size re-estimation designs using a promising zone framework are widely used adaptive trial methodologies that guide study continuation or modification during interim analyses. Conventional implementations often base interim calculations solely on participants with available primary endpoints, overlooking predictive information from baseline and earlier visits. This underutilization can lead to inefficient interim decision-making. In this work, we adapt semi-parametric efficient estimators...

May 9, 2026Read Abstract →

Covariate adjustment in randomized clinical trials: From general theory to practical insights

Covariate adjustment uses baseline prognostic variables to improve the precision of treatment effect estimates. Recent Food and Drug Administration guidance and scientific consensus emphasize three principles for its use, namely estimand-focused analyses, assumption-lean robustness, and fit-for-purpose variance estimation. Despite substantial methodological progress, practical guidance for trial practitioners remains fragmented. We review covariate adjustment strategies for continuous, discrete,...

May 9, 2026Read Abstract →

Trastuzumab Deruxtecan-Induced Interstitial Lung Disease: A Systematic Review and Meta-Analysis of Clinical Trials and Real-World Evidence

IntroductionTrastuzumab deruxtecan (T-DXd)-induced interstitial lung disease/pneumonitis (ILD) represents a clinically significant and potentially fatal toxicity. Discrepancies exist regarding its reported frequency and severity between clinical trials (CTs) and real-world data (RWD). This meta-analysis aims to evaluate the incidence of T-DXd-related ILD and investigate its differences between CTs and RWD.MethodsA systematic review and meta-analysis was conducted in accordance with the PRISMA...

May 9, 2026Read Abstract →

Tracking Symptom Change Across Therapy Sessions in Virtual Reality Cognitive Behavioral Therapy Versus Cognitive Behavioral Therapy for Paranoid Ideation: A Secondary Analysis of a Randomized Controlled Trial

CONCLUSIONS: Therapists observed faster symptom recovery in paranoia and avoidance in VR-CBTp while requiring fewer sessions than standard CBTp. These findings suggest that VR-CBTp may be more efficient in duration, while broader effects on access and therapist workload remain to be determined.

May 9, 2026Read Abstract →

Effects of Empagliflozin and Lifestyle Intervention on Improving Body Weight and Other Metabolic Parameters in Atypical Antipsychotics-treated Patients with Schizophrenia Spectrum Disorders-A Double-blind Randomized Placebo-controlled Trial

CONCLUSIONS: The combined approach of empagliflozin and lifestyle intervention improved weight control and glucose metabolism among patients with schizophrenia spectrum disorders receiving atypical antipsychotics.

May 9, 2026Read Abstract →

Effectiveness of Cognitive Behavioral Therapies Targeting Cognitive Biases and Beliefs in Schizophrenia-Spectrum Disorders: A Systematic Review and Meta-Analysis

CONCLUSIONS: CBT produces small but reliable improvements in dysfunctional beliefs in SSD, although effects vary by domains particularly for delusional conviction and self-schemas, supporting their role as modifiable therapeutic targets and plausible mechanisms of change. Effects on cognitive biases remain limited and understudied.

May 9, 2026Read Abstract →

Optimal Designs in Open-Cohort Longitudinal Cluster Randomized Trials With a Continuous Outcome

Although sample size calculation for open-cohort longitudinal cluster randomized trials (LCRTs) under a fixed design framework was developed by Kasza et al., unifying the closed-cohort and repeated cross-sectional sampling provided in Hooper et al. when a churn rate is constant, there has been no prior efforts in developing optimal open-cohort LCRTs that maximizes the design efficiency. This work assumes a prespecified number of periods T $T$ and a constant number of replaced individuals at...

May 9, 2026Read Abstract →

Effect of Ultrasound-Guided Lateral Infraclavicular Brachial Plexus Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures: A Randomized Controlled Noninferiority Trial

CONCLUSION: Lateral infraclavicular block with ropivacaine 0.2% failed to demonstrate noninferiority for block success and was statistically inferior to ropivacaine 0.5%. Inferiority testing should be interpreted cautiously within the context of a noninferiority design, although the results suggest reduced effectiveness for distal radius fracture reduction. Lidocaine 1% with epinephrine yielded inconclusive results for noninferiority on block success, but provided a shorter block duration...

May 9, 2026Read Abstract →

Clinical and cost-effectiveness of negative pressure wound therapy versus usual care for surgical wounds healing by secondary intention: the SWHSI 2 pragmatic RCT

CONCLUSIONS: Negative pressure wound therapy is not clinically or cost-effective in augmenting healing in patients with surgical wounds healing by secondary intention, particularly those with comorbidities.

May 9, 2026Read Abstract →

Stem cell-based therapies for type 1 diabetes: Progress in differentiation, clinical translation, and immune protection

Transplantation of insulin-producing cells derived from pluripotent stem cells represents a highly promising approach for the radical treatment of type 1 diabetes (T1D). Informed by a comprehensive understanding of fetal pancreatic development, directed differentiation protocol for generating pancreatic β cells from pluripotent stem cells has been established and has achieved considerable advances, enabling the production of mature, fully functional β cells that closely recapitulate the...

May 9, 2026Read Abstract →

A Systematic Review on Disease-Modifying Therapies in Parkinsonian Disorders

Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease-modifying therapies that have been evaluated in clinical studies across these disorders, based on a comprehensive literature search up to May 2025. Eligible studies included clinical trials...

May 9, 2026Read Abstract →

Population pharmacokinetics and exposure-response modelling of firsekibart (GenSci048) in patients with acute gout flare: Implications for fixed-dose optimization

CONCLUSION: Firsekibart demonstrated predictable pharmacokinetics, a favourable safety profile, and robust efficacy coverage at the 200-mg fixed dose. These findings support fixed-dosing for patients with acute gout flares who are intolerant of, unsuitable for, or inadequately responsive to standard-of-care therapies.

May 9, 2026Read Abstract →

Luminal Peri-Anastomotic Antibacterial Washout to Prevent Colorectal Anastomotic Leakage: A Pilot Audit of Outcomes

CONCLUSION: Peri-anastomotic luminal washout with antibiotics is feasible and safe. It does not appear to have deleterious effects and should be compared to peri-operative oral antibiotics in larger clinical trials.

May 9, 2026Read Abstract →

Capnography With Integrated Pulmonary Index for Preventing Hypoxemia During Pediatric Urologic Surgery Under Sedation: A Randomized Controlled Trial

BACKGROUND Procedural sedation and analgesia (PSA) can relieve pain and anxiety during invasive procedures. Carbon dioxide (CO₂) monitoring or integrated pulmonary index (IPI) can reduce respiratory depression in adults with PSA, but the effect of the combination of these 2 methods on intraoperative hypoxemia in pediatric urologic surgery is unclear. This study was conducted to determine whether capnography combined with IPI could lessen intraoperative hypoxemia during pediatric urinary...

May 9, 2026Read Abstract →

Porcine kidney xenotransplantation: From primate models to clinical reality

The escalating global incidence of end-stage renal disease has exacerbated the critical shortage of kidneys from human donors. Porcine kidney xenotransplantation has emerged as the most promising alternative solution to providing an unlimited organ supply. In this review, we examine the historical evolution, current breakthroughs and future directions of kidney xenotransplantation. We probe the milestones from early attempts and non-human primate (NHP) experiments to recent clinical trials...

May 9, 2026Read Abstract →
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