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CONCLUSIONS: We demonstrated long-term real-world outcomes of nivolumab-plus-ipilimumab. Our findings support prescriptions of nivolumab-plus-ipilimumab in real-world clinical practice.
CONCLUSIONS: Sanopal® did not alter hemoglobin-oxygen affinity or SpO₂ under resting conditions in normoxia or acute hypoxia. After exercise at altitude, it slightly increased Hb-O₂ affinity without significantly affecting SpO₂ or other measured blood parameters. The modest increase in Hb-O(2) affinity following exercise may have limited the exercise-induced decrease in Hb-O(2) affinity. However, this increase was likely too small to significantly raise SpO₂ in this cohort at a relatively low...
CONCLUSIONS: Artificial intelligence has the potential to enhance clinical nursing decision-making, although evidence is limited by too few examples of nurse participation during development. Underutilisation in administrative nursing functions hinders implementation. Nurses should assume a central role in the design and development of AI applications to ensure that these technologies address the realities of nursing practice. With such improvements, artificial intelligence can transform nursing...
CONCLUSION: The findings highlight that challenges were amplified during the pandemic, underscoring the urgency for healthcare providers and policymakers to address these concerns. Findings can inform improvement of post-pandemic maternity care to enhance birth experiences and guide emergency preparedness, protecting the needs and rights of birthing women, including permitting a companion of choice, reducing maternal-infant separation and providing early breastfeeding support.
CONCLUSIONS: Appropriately handling missing PRO data in patients completing treatment can reduce bias and improve the validity and reliability of efficacy analysis, potentially enhancing the ability of detecting therapeutic effects. This strategy should be considered in future clinical trials of IBD.
CONCLUSION: Although preclinical studies were promising, comprehensive clinical trials of IL-1 family and inflammasome inhibitors are required for translating current research into viable treatments for patients with dental pulpitis. Future work should prioritize clinical validation to enable implementation in patient care.
INTRODUCTION: Targeted therapies have improved both efficacy and safety profiles in chronic lymphocytic leukemia (CLL). Nevertheless, they present novel challenges in patient selection, particularly within aging populations wherein individuals aged over 80 years remain underrepresented in clinical trials.This review examines how frailty and biological aging intersect with CLL to inform risk stratification, treatment decisions, and supportive care.
Venous leg ulcers (VLU) are a major complication of chronic venous disease, with compression therapy as the gold-standard treatment. This 2 × 2 factorial randomised open-label trial assessed the effect and three-month sustainability of a one-hour training intervention on compression bandaging quality among 50 advanced practice nursing students (APNS) in France, using two different compression bandage types (system A or system B) on a mannequin leg. The primary outcome was the Control Score of...
Topical ruxolitinib 1.5% cream is the first approved therapy for repigmentation in non-segmental vitiligo. However, treatment response varies, and reliable predictors of efficacy remain undefined. This narrative review examined clinical trials and observational studies investigating factors associated with response to ruxolitinib cream. A comprehensive search of MEDLINE, Cochrane CENTRAL and ClinicalTrials.gov (through June 2025) identified 14 eligible studies. Anatomical site was the most...
This manuscript advocates for the implementation of multiple-sequence cross-over designs in early-phase clinical trials by investigating the bias in within-subject variance present in paired and AB/BA cross-over clinical trial designs. While the advantages of adding additional sequences to mitigate confounding effects are well established, the authors noted a lack of mathematical discussion regarding the estimation of random effects in early-phase trials-an important consideration for planning...
CONCLUSION: Isotretinoin with desloratadine offers superior efficacy and tolerability, ensuring higher patient satisfaction without safety risks.
BACKGROUND: The HIT network was established in 2000 to create a population-based structure aiming to improve survival rates and reduce late effects for children with central nervous system (CNS) tumors by conducting comprehensive clinical trials.
Pediatrics often faces ethical challenges when families request unproven therapies. We respond to a clinical case described in "A Parental Request for an Unproven Treatment for a Rare Pediatric Cancer: Sound Reasons for Not Going Off-Label," by Margot Hedlin and Louis Voigt, in the same issue of this journal. The case concerns Natalie, a three-year-old in remission from ependymoma, whose parents requested metformin to prevent recurrence. Although Natalie's neuro-oncologist opposed the use of the...
This study compared Intraneural Facilitation (INF^(®)) therapy and standard physical therapy (PT) in preventing chemotherapy-induced peripheral neuropathy (CIPN) in women with newly diagnosed breast and gynecologic cancer. Thirty-eight women undergoing platinum and/or taxane-based chemotherapy, without prior peripheral neuropathy, were randomized into INF^(®) therapy (n = 20) and PT (n = 18). Treatments lasted 45 minutes, twice weekly, for 6 weeks. Neuropathy severity was evaluated using the...
CONCLUSIONS: LNG-IUS is highly cost-effective compared with HNR for the treatment of niche-related postmenstrual spotting at 6 months. These findings support LNG-IUS as first-line therapy for niche-related spotting in women with a residual myometrium ≥2.2 mm.